Highlights
- •CTRCD significantly contributes to the global burden of cardiovascular disease.
- •Comprehensive cardiac monitoring may be useful during and after cardiotoxic chemotherapy.
- •Echocardiography and cardiac biomarkers play pivotal roles to detect CTRCD.
- •Early detection and prompt treatment of CTRCD may improve the prognosis in cancer patients.
- •Close collaboration between oncologists and cardiologists is becoming more and more important.
Abstract
Although recent advances in cancer treatment improve cancer prognosis, cancer therapeutics-related
cardiovascular dysfunction (CTRCD) significantly contributes to the global burden
of cardiovascular disease. CTRCD causes two crucial issues: first, premature treatment
interruption or discontinuation of chemotherapy; second, the development of congestive
heart failure during and after cancer treatment. Thus, early detection and prompt
treatment of CTRCD may improve the prognosis in cancer patients. This review covers
representative anticancer drugs, including anthracyclines, human epidermal growth
factor 2 inhibitors, tyrosine kinase inhibitors, proteasome inhibitors, and immune
checkpoint inhibitors. We focus on the molecular mechanisms of CTRCD and various approaches
to diagnosis, prevention, monitoring, and treatment.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: May 17, 2022
Accepted:
April 14,
2022
Received:
April 13,
2022
Identification
Copyright
© 2022 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. All rights reserved.
