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Letter to the Editor|Articles in Press

Understanding and modifying thrombotic risk in patients with myeloproliferative neoplasms

Published:January 31, 2023DOI:https://doi.org/10.1016/j.jjcc.2023.01.007
Understanding and modifying thrombotic risk in patients with myeloproliferative neoplasms
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      We thank the authors for their interest in our recently published paper [

      Krecak I, Sabljic A, Lucijanic M. Understanding and modifying thrombotic risk in patients with myeloproliferative neoplasms. JCardiol

      ,
      • Leiva O.
      • Jenkins A.
      • Rosovsky R.P.
      • Leaf R.K.
      • Goodarzi K.
      • Hobbs G.
      Predictors of increased risk of adverse cardiovascular outcomes among patients with myeloproliferative neoplasms and atrial fibrillation.
      J Cardiol. 2022; (in press)
      ]. We agree that the pathophysiology of thrombosis in patients with myeloproliferative neoplasms (MPNs) is multifactorial with contribution of non-traditional cardiovascular (CV) risk factors [
      • Leiva O.
      • Hobbs G.
      • Ravid K.
      • Libby P.
      Cardiovascular disease in myeloproliferative neoplasms.
      JACC CardioOncol. 2022; 4: 166-182
      ]. However, the magnitude of the contribution of these risk factors in this patient population (leukocytosis, JAK2 mutational status, etc) on CV and non-CV prognosis is yet to be defined [
      • Mancuso S.
      • Santoro M.
      • Accurso V.
      • Agliastro G.
      • Raso S.
      • Di Piazza F.
      • et al.
      Cardiovascular risk in polycythemia vera: thrombotic risk and survival: can cytoreductive therapy be useful in patients with low-risk polycythemia vera with cardiovascular risk factors?.
      Oncol Res Treat. 2020; 43: 526-530
      ].

      Keywords

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      References

      1. Krecak I, Sabljic A, Lucijanic M. Understanding and modifying thrombotic risk in patients with myeloproliferative neoplasms. JCardiol

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        • Leiva O.
        • Jenkins A.
        • Rosovsky R.P.
        • Leaf R.K.
        • Goodarzi K.
        • Hobbs G.
        Predictors of increased risk of adverse cardiovascular outcomes among patients with myeloproliferative neoplasms and atrial fibrillation.
        J Cardiol. 2022; (in press)
        View in Article
        • Leiva O.
        • Hobbs G.
        • Ravid K.
        • Libby P.
        Cardiovascular disease in myeloproliferative neoplasms.
        JACC CardioOncol. 2022; 4: 166-182
        View in Article
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        • Accurso V.
        • Agliastro G.
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        • Di Piazza F.
        • et al.
        Cardiovascular risk in polycythemia vera: thrombotic risk and survival: can cytoreductive therapy be useful in patients with low-risk polycythemia vera with cardiovascular risk factors?.
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      Article info

      Publication history

      Published online: January 31, 2023
      Accepted: December 19, 2022
      Received: December 18, 2022

      Publication stage

      In Press Corrected Proof

      Identification

      DOI: https://doi.org/10.1016/j.jjcc.2023.01.007

      Copyright

      © 2023 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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