Highlights
- •Phase variables can be obtained fully automatically from ECG gated SPECT-MPI.
- •Phase analysis has predictive and prognostic value in various clinical situations.
- •Phase variables should be routinely reported for SPECT-MPI studies.
Abstract
Electrocardiogram (ECG)-gated single photon emission computed tomography myocardial
perfusion imaging (GSPECT-MPI) is widely used for assessing coronary artery disease.
Phase analysis on GSPECT-MPI can assess left ventricular mechanical dyssynchrony quantitatively
on standard GSPECT-MPI alongside myocardial perfusion and function assessment. It
has been shown that phase variables by GSPECT-MPI correlate well with tissue Doppler
imaging by echocardiography. Main phase variables quantified by GSPECT-MPI are entropy,
bandwidth, and phase standard deviation. Although those variables are automatically
obtained from several software packages including Quantitative Gated SPECT and Emory
Cardiac Toolbox, the methods for their measurement vary in each package. Several studies
have shown that phase analysis has predictive value for response to cardiac resynchronization
therapy and prognostic value for future adverse cardiac events beyond standard GSPECT-MPI
variables. In this review, we summarize the basics of phase analysis on GSPECT-MPI
and usefulness of phase analysis in clinical practice.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: March 11, 2023
Accepted:
February 10,
2023
Received:
January 31,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
